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Coffee Time Audio: Audiophile-grade, noise-free. Performances: in the living room, from left,. They are one of the most accomplished bands of the past century, and their new CD, «No Regrets». Free download: Ultimate Guitar Archive of the best guitar solos and other great musical.Oestrogen-induced delayed neuronal death is associated with alterations in SDF-1 expression in the rat brain.
Delayed neuronal death is a key pathogenetic process in the female brain. In the present study, we examined whether an alteration in the expression of stromal cell-derived factor-1 (SDF-1) in neurons is involved in oestrogen-induced delayed neuronal death. To this end, we investigated the SDF-1 mRNA expression in the female rat brain and at different times after an induction of oestrogen-induced delayed neuronal death with a neurosteroid, alphaxalone. Oestrogen increased SDF-1 mRNA expression in cells in the fimbria and hippocampus of the female rat brain. This increase started at 72 h and lasted up to 96 h after the application of oestrogen. No significant changes in the expression of SDF-1 were observed in cells of the corpus callosum. The specific downregulation of protein kinase C activity by prolonged treatment with a specific inhibitor of protein kinase C, calphostin C, started at 48 h after the induction of delayed neuronal death and continued to 96 h after the induction of delayed neuronal death. This downregulation was associated with an increased expression of SDF-1 in the fimbria and hippocampus. Furthermore, a blockade of oestrogen-induced delayed neuronal death with calphostin C indicated that SDF-1 in the female rat brain is involved in oestrogen-induced delayed neuronal death. Taken
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